I will let you in on my speed secrets.
Try different sprocket combos. I run 15/44 when I want to drag race since the 500 has the power to get my fat butt going. Some times someone will crawl ahead of me at the start but when the 500 winds up into the power band it's all over for them. I'm 6'4" at 290 so I have to feather the clutch on my starts due to the sprocket ratio.
When I get ahead of them I move over in front of them so they can look through my dust cloud. Sometimes they think I,m still in my lane and they will move over to the wrong side and have to hit the brakes. I never said I would play fair.
On my starts I have both feet on the ground in front of the foot pegs. This accomplishes two things; it keeps my legs from wanting to move backwards which, if you watch a lot of starts, the guys legs want to naturally move backwards which just unloads the front and takes you out of the forward/nuetral/balanced position. Secondly when I go for second gear I raise both legs straight up on their way to the pegs but I let off the throttle for just a fraction of a second, and snag the shifter with my boot on the way up. I don't use my clutch when I drag race

unless you are a pro rider you can't shift as fast as I can using this technique, every time the clutch and throttle are used together you lose forward momentum. Ask around and find out what a 450 tops out at. I know my 500 can hit 125 with my son-in-law on it.
Of course I will try to jet the carb to fit the conditions, I also run my premix at 20:1 which allows more gas to be in the cylinder when it fires.
I have also found (by accident) that the length of the silencer has an effect on where the torque curve happens in the power band. I use a long silencer for the woods because I feel the motor has more torque lower in the rpm range.
I ride in the mountains mostly so I have no advice on racing a 450 on a track. I gave that up a long time ago in the interest of self preservation. I do have a nephew that can beat a 450 on a two smoke 125 at the track but that's because of his ability to go flat out on any bike he gets on and he is a very technical rider.
Practice,Practice,Practice until your tired of it and then practice some more.